Research- Chronic pain is not all in the brain.

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Research- Chronic pain is not all in the brain.

Postby perseus » Tue Nov 25, 2014 10:32 am

......As with other chronic pains, many of us experts have been assuming the main problem for these patients is in the brain. But it recently emerged that the blood of patients with this condition carries specific immune substances, termed “autoantibodies”. These substances can probably cause pain by binding to peripheral tissues, prompting sensory nerves to misfire – although the exact pathway is not understood. Misfiring of sensory nerves results in a state where the central nervous system, including the brain, has become “wound up”.

In CRPS, peripheral nerves may thus play a role comparable to electronic transistors: with very low abnormal peripheral input generated by the autoantibodies, the nerves steer a massive central abnormality. Without trauma these newly discovered antibodies are probable harmless; the trauma-induced inflammation is required to render them harmful.

In fact, these antibodies may only be present for a limited time, during a “window of vulnerability”, in sufficiently high concentration to cause harm after trauma; the same trauma sustained either earlier or later may not trigger CRPS. The good news is that there are treatment methods, originally established for the treatment of other diseases designed to reduce or remove auto-antibodies, which can now been tried.

So chronic pain is not all in the brain. Abnormal peripheral nerve activity (phantom limb pain), or peripheral immune activation (CRPS) are probably the main culprits for causing some chronic pain conditions, and this should become treatable.


https://theconversation.com/chronic-pain-isnt-all-in-the-brain-which-is-good-news-for-sufferers-34632
As a Public Moderator of this forum my opinions/views expressed are personal and are no more valid than those of other members and not necessarily those of UKFibromyalgia. Regards Stephen
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