High tolorance to medication

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High tolorance to medication

Postby pinkfairygirl » Thu Apr 29, 2010 11:57 pm

I wondered if what my specialist said is true, that people with CFS and or FM have a low tolorance to medication?

The thing is with me I have an extremely high tolorance to medication. I'm now taking 100mg of Amitriptyline (for pain) and 60mg of Duloxetine (Duloxetine being used for depression as well as for pain). My normal doc said the Duloxetine should act as a pain killer too. Two weeks ago I suddenly got a bad attack of pain in the top of my left arm and into my neck. I rung my surgery and my normal doctor was away so another doc increased my Ami from 20mg to 100mg. So I saw my normal doctor two days ago and I told her the Ami had been increased and she was like :shock:. The fact is I still get some pain on the Ami too, but it's a lot better then without.

The thing that my doctor, I think was shocked about is I'm getting no side affects. First couple of days I did. But now nothing at all. And there is no effects either from the Ami and Duloxetine interacting. They are not the only drugs I have found myself highly tolorant to. I have to take Domperidone and Ondancetron as one will not work along even at a high dose. I can take 10mg of Nitrazepam and 15mg of Valium and hardly be affected at all. In fact last time I was perscribed Valium the doc told me to take 30mg, few days later my CPN came around and I told her how much Valium I was taking and she was :shock:. I was my normal self, tired and suffering my normal FM and CFS symptoms but nothing else.

Now some of you probably know that drugs like Valium you can get a tolorance too. But that happends if you take it very regularly and I don't, infact I haven't had any since Feburary as there is no point, it doesn't work. My CFS specialist put me on Acyclovir as he thinks I have a form of glandular fever, I read all the side effects and was dreading taking it. But once I started it, again nothing changed, no side effects what so ever. Also it hasn't don't anything to get rid of the symptons I am having so my GP said not to bother continuning with it.

Also I have been put on Thyroxine to help me have more energy. It has made me a little brighter but nothing major. And again no side effects. My GP said it would probably cause me heart to beat faster, but I already have that and it hasn't changed since taking Thyroxine.

I don't understand exactly how my body is taking all this medication and not reacting in a negitive way. And not many of the drugs even help me much. I really was building up my hopes that the Acyclovir was going to work as I have been getting hot flushes (I'm 24 so not menopulse) and sweats, fast and hard heart beating and almost collapsing with breathlessness.

Over the last few weeks I have developed a perminant cold. I am worried this will not go away as what drug can they use that I'm not going to be highly tolorant to? The thing that also worries me is my liver is not always going to be able to take the high volium of drugs I have to take much longer. My GP doesn't seem worried but I am.

Am I the only one that has this? And why the heck am I like it? I guess it must be my genes or something.
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Re: High tolorance to medication

Postby hamstergirl » Fri Apr 30, 2010 7:15 am


I have a very low tolerance to drugs.

If you are worried about the effect of your liver I would stop the drugs that you think are not doing anything for you. Discuss it with your Doctor first though.

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Re: High tolorance to medication

Postby shazq » Fri Apr 30, 2010 12:17 pm

I know a lot of fibro sufferers have a low tolerance in meds me included, i get side effects very early after starting a new med, i have to increase them very slowly.

Hope you find a med that works for you, as you must be in lots of pain if the meds are taking no effect. :hugs:
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Re: High tolorance to medication

Postby LinzWorld » Mon May 03, 2010 7:19 pm

I have a high opioid tolerance, but that is quite common amonst fibromites and hyerpmobile people. Other meds not usually, but do remember that some meds just don't work on some people and you could take any dose and they wouldn't do much.

Ami isn't recommended for Fibro at doses higher than 50mg. It can be hard to tell if you're getting side effects as the most common one is fatigue or lethargy and this can increase gradually the longer you take it.

Also, domperidone is a dopamine antagonist so it has the potential to worsen or perpetuate Fibro symptoms.
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Re: High tolorance to medication

Postby gillshutt » Thu May 06, 2010 3:48 pm

Low tolerance here... was tried on anti d's when I first started with fibro and a gp decided I was depressed without asking me anything to find out... I took one tablet and ended up in A&E :shock: Now I'm not allowed SSRIs even if I should get depressed.

Antibiotics affect me one way or another as well... have been out of it for the last week as was put on antibiotics for a water infection I didn't have (long story) the tabs made me woozy liek I'd had a few too many, then sleepy then I got a hangover :evil: That's the 2nd lot I can't take now.

Butrans patches made me want to sleep or kill people... can't take them.

Ami's made me a complete zombie on the lowest dose... can't take them.

Anti vertigo tabs give me vertigo.

Tabs to help coat my stomach make me sick...

You get the picture. :lol:
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Re: High tolorance to medication

Postby Muireann0478 » Thu Jul 01, 2010 9:10 pm

I have a high tolerence of everything too and it stuns my doctors that I am not on the floor however whenever I complain about Fibro Fog or something like that they brush it off as "oh well, with all the meds your on it's just side effects" which is so frustrating when I know its not.
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Re: High tolorance to medication

Postby Gatwick Gal » Wed Aug 11, 2010 12:02 pm

I also have a high tolerance to opioides & valium. When i took atitriptoline i was on 200mg a day in a short period of time & it workd for a while but it ended up making me feel worse than without it & now if i take 1 i will blow up.i get the neg side effects quickly,but have hgh tolerance once get over them,if i can cope we them long enough. Just now im only on 300mg of tramadol,(previously i was on 1200mg of ramadol,befor getting diagnosed upon moving to horley)& 15mg of valium. I've tried all the anti depressants with no joy frm any except the antitriptoline for a short time. I've been in tht much pain the past couple wks tht my son keeps tellin me to go to A & E,as he says i'll get pain relief n a ? about the pain,as he usd to work there,next time im in tear due to pain i will do just tht as i need to do something to get someone to perscribe me something that will help.

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Re: High tolorance to medication

Postby piglet_mini » Wed Aug 11, 2010 9:51 pm

HIGH tolerance here - 75mg fentanyl patch (worn 24/7), 100mcg sublingual fentanyl 4x day, 200mg zr tramadol x2 day, 5mg diazepam x3 day, 25mg amitriptyline at night & 10mg oramorph when needed - I function fine, can drive most days (pain allowing) I find it hard that I take all these meds and I still get pain. My GP only believes I get fibro fog as I end up blacking out - today being classic, fell down stairs and cant remember getting up today been so fuzzy :(
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Re: High tolorance to medication

Postby Schip » Fri Aug 13, 2010 7:14 pm

I have no tolerance am now at point of being unable to take any meds even vits etc since Feb, got an immunologist appointement next mth.

Can't take antihistamines, inhalers are a struggle all cause shock like symptoms, breathing problems, very high bp and heart rate, shakes, nausea, burning mouth, lips and tongue, excess phlegm in my throat for upto 7 days on just one dose.
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