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The UKFibromyalgia Forums • View topic - medication - intolerance



medication - intolerance

All your questions and experiences of medication and treatments on the NHS or Private Healthcare.

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medication - intolerance

Postby Ulysse » Mon Mar 11, 2013 6:20 pm

I am extremely intolerant of most drugs I am offered, especially those which would help with pain and depression. Do many of find this. I cannot take anti-inflammatories, opiate based drugs like Tramadol, tried Effexor (though I was dying after only one) also tried Laroxyl.
25mg, took one and slept for almost 24 hours. Taking Daflon 500mg for vein problems at present, anyone had any experiences of this giving hot flushes?
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Re: medication - intolerance

Postby Pipsie » Mon Mar 11, 2013 6:59 pm

Yeah, I can't take anti inflammatories, most anitbiotics, and pain killers. I put up with side effects of most of them as they're better than a slap in the face. Ho-hum.
You may want to try other pain killers, there are a whole world of them out there that one's GP won't tell you about cus they cost a bomb. Also things like gabapentine can help with pain. Go see your GP, and have a long talk with them about getting round this problem. Holistic treatments may provide some relief, too.
Feel better soon! :)
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Re: medication - intolerance

Postby deanna dimech » Mon Mar 11, 2013 7:06 pm

you need to ask to go to the hospital pain management team, i cannot take tramadol codine and anything morphine based but i have been given pregabalin nortriptyline and etodolac so there is hope for you. good luck
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Re: medication - intolerance

Postby FluppyPuffy » Mon Mar 11, 2013 9:15 pm

Sensitivities and intolerances are fairly common with FM, so what you're experiencing is something that is shared by quite a few on here, not just with meds, but also other things. I have major problems with herbally/alternative treatments and supplements.

Sometimes, when a first med proves unsuitable, another from the same classification can turn out to be better tolerated.


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Re: medication - intolerance

Postby not.giving.in » Tue Mar 12, 2013 10:38 am

As above, intolerance is very common with fibro, as is intolerance of opiates - any drug related morphine. I feel for you :( but don't ever give up. I don't bother with over the counter pain relief as it doesn't usually help much and is hard to keep down. I get bizarre reactions to a lot of drugs, sometimes the opposite to the one intended :-P I do use amitriptylene and gabapentin successfully for the pain and it's worth a try as they work differently from ordinary analgesics. They work to lift the levels of the chemicals in your brain that counter pain signals. GP's don't have specialised skills in pain management, they have to have a good working knowledge of too many issues to focus on just one. Ask for referral to a pain clinic and ask the consultant to give you the minimum dose of anything you try so you can build it up gradually. Fibro patients often work best on lower doses than normally prescribed.

Good luck, keep :lol: Gentle Hugs :-)
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Re: medication - intolerance

Postby Ulysse » Wed Mar 13, 2013 10:36 pm

Thanks for the replies.

I live in France and spent four days last week at a pain clinic in Nantes. I was given Ketamine intravenously for four days. Starting at 15mg per hour normally for 3 hours and then dropping to 2mg per hour and then up to 4mg per hour. I couldn't tolerate the 15mg for more than about one hour as my head was spinning and I was freezing cold and shaking. I only managed the 4mg an hour for about 3 hours. For the last 18 hours they added Laroxyl to the drip which just sent me to sleep. The pain level whilst at the clinic was lower but I wasn't doing anything. On the journey home (2 hours) my neck and hand were really painful and since then I have had my normal level of pain. I go back to see the Dr in June for an evaluation. I got the impression that many of the other patients had been several times before but weren't getting much relief.

The doctor gave me a prescription for 25mg of Laroxyl to take at night, i only took one and slept almost solidly for 24 hours. I didn't take any more. I am going to ask to try the lowest dose, 10mg to see if i can sleep at night with that, but not during the day too!! I am a bit scared of the pills to be honest, I took just 1 Effexor (Venlafaxine) and had the most horrendous experience, i thought i was going to die during the night and only had about one hours sleep.

I also suffer from sensitivity to soaps, creams, dust household cleaners etc etc!

I am going to meet with a Commision tomorrow morning who will decide if I can have an invalidity allowance as I cannot work due to the pain of FMS and also polyarthritis. I feel like i am doing battle all round.
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