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The UKFibromyalgia Forums • View topic - Is it safe to take 5htp with Nortriptyline?



Is it safe to take 5htp with Nortriptyline?

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Is it safe to take 5htp with Nortriptyline?

Postby JemmaB88 » Sun Mar 17, 2013 1:22 pm

Hello all,
Quick question. Is it safe to take 1x 5htp capsule along with 1x 10 mg nortriptyline tablet? I have only just started on the nortriptyline hence the low dose. I took 5htp for a little while about 6 months ago but stopped due to a bad ibs flare.
Should I just take the nortriptyline for now and speak to the doc at the review in a few weeks?
Also while I am here, do I need a letter from the doc for meds when travelling to the states?
Thanks
Jem
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Re: Is it safe to take 5htp with Nortriptyline?

Postby kazza65 » Sun Mar 17, 2013 1:31 pm

Wouldn't mix anything with prescribe drugs from doctor. YOu never know what my happen. As for the letter for the medication for travelling to the states. I think you need a letter when traveling aboard about your medication to prove it yours
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Re: Is it safe to take 5htp with Nortriptyline?

Postby FluppyPuffy » Sun Mar 17, 2013 2:09 pm

Don't take the 2 of them together Jem. Nortriptyline is an SSRI like amitriptyline and 5HTP also works on serotonin levels

SSRIs are believed to increase the extracellular level of the neurotransmitter serotonin by inhibiting its reuptake into the presynaptic cell, increasing the level of serotonin.

5-HTP is an amino acid that occurs naturally in the body, and plays an important role in the production of serotonin in the brain. Serotonin serves a number of functions, but in the brain it is principally involved in mood-regulation; the higher our serotonin levels in the brain, the happier we feel. By taking 5-HTP in supplement form, we are essentially providing more resources for the brain to manufacture serotonin, increasing our serotonin levels, and potentially alleviating bouts of depression and anxiety.

However, if 5HTP is taken with an SSRI, such as nortriptyline, it can cause a potentially life threatening drug reaction that causes the body to have too much serotonin, a chemical produced by nerve cells. This reaction is known as Serotonin Syndrome.

Symptoms of Serotonin Syndrome can occur within minutes to hours, and may include:
Agitation or restlessness
Diarrhea
Fast heart beat and high blood pressure
Hallucinations
Increased body temperature
Loss of coordination
Nausea
Overactive reflexes
Rapid changes in blood pressure
Vomiting

This linky has more info on the condition http://www.nlm.nih.gov/medlineplus/ency ... 007272.htm

IMO, sticking with the nortriptyline for now would be the best option and see how you go on with it for the next few weeks until your review. Like amis, they can take about a month to fully get into your system and take effect, plus some twiddling with dosage may be needed to find the right level for you.

According to U.S. Customs and Border Protection, a GPs letter and /or prescription is required on all meds when entering the States. The prescription seems to be needed as well as the letter if meds are not in their official packaging.


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Re: Is it safe to take 5htp with Nortriptyline?

Postby JemmaB88 » Sun Mar 17, 2013 6:36 pm

Thanks guys. I wasn't sure as the pharmacy gave me a bottle of pills with no data sheet. They aren't the most helpful bunch either. Will give it a month on the pills. I fly out to florida in 5 weeks. I hope they are working by then!!
Thanks again. Best support on here :)
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