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The UKFibromyalgia Forums • View topic - Flupiritine
Page 1 of 2

Flupiritine

PostPosted: Mon Jul 29, 2013 10:07 pm
by TATT
Dear All,

I am on Flupiritine and have been for about 4/5 months, it helps relax me and helps me sleep. For anyone also taking this please read the below link which I found today. As we know Prof Davies is no longer with us and it's where I got it prescribed so I need to see my GP. Just a heads up for others using it



Tatt

Re: Flupiritine

PostPosted: Mon Jul 29, 2013 11:36 pm
by FluppyPuffy
TATT, just tried your linky and it goes to a page that needs logging into.

Re: Flupiritine

PostPosted: Mon Jul 29, 2013 11:49 pm
by Iceskatemum
Sorry folk have tried both linkys and still need to log in to the page.

You had mentioned this before Tatt in another thread and when I was at my last visit to the pain clinic my consultant had never heard of it but I had brought information you had directed us to and so he then tried to look it up in the NHS system. It seems it is not in the allowed medicines list ( my name not the official name) hence the private script which I think you had from Prof Davis.

I am so glad it is working for you . It is good to get your feed back.

Would still consider it although with Professor Davis death it might be more difficult to get even though it seems it is used in Europe quite a bit.

Good luck

Re: Flupiritine

PostPosted: Tue Jul 30, 2013 12:15 am
by FluppyPuffy

Re: Flupiritine

PostPosted: Tue Jul 30, 2013 10:21 am
by TATT
Sorry, when I tried the link it went straight to the subject.

FP I have copy and pasted the subject below.

ISM it has been helping me sleep and relax but as you can see it damages the liver and is only allowed for two weeks. Since Prf Davies passed away another doctor has in his placed given me another three months supply. After finding this yesterday I have stopped taking the drug and wanted others to know about it too. I know other patients of his are on the drug.

Back to the drawing board again. But at least I hope with a decent liver.

Tatt

Re: Flupiritine

PostPosted: Tue Jul 30, 2013 10:28 am
by TATT
Actually this is the post, sorry had a fibro moment. :roll:


The European Medicines Agency's (EMA) Co-ordination Group for Mutual Recognition and Decentralised Procedures–Human (CMDh) has endorsed by a majority new recommendations to restrict the use of flupirtine-containing oral medicines and suppositories, the EMA announced today.

These analgesic medications should now only be used for treating acute pain in adults who cannot use other agents such as nonsteroidal anti-inflammatory drugs (NSAIDs) and weak opioids, and treatment should not last longer than 2 weeks, a statement released today notes.

For patients who are treated, liver function testing should be done after each full week of treatment and the medication should be stopped if any signs of liver damage occur. Patients with pre-existing liver disease or alcohol abuse problems, or who are taking other medications known to affect the liver, should also not take flupirtine-containing medications, the statement adds.

The recommendations follow a review by the EMA's Pharmacovigilance Risk Assessment Committee (PRAC) of available data on liver safety with this agent, released June 14, and reported by Medscape Medical News at that time, looking at 330 adverse event reports ranging from elevated liver enzymes to liver failure. PRAC noted that there were no cases of liver failure or transplantation among those treated for 2 weeks or less, and that although there were data from studies in acute pain, there were insufficient data to support long-term use, that is, longer than 8 weeks.

PRAC also reviewed the use of injectible flupirtine used as a single injection for pain after surgery, and concluded that the benefits continue to outweigh the risks for the drug used this way.


"The CMDh agreed with the PRAC's conclusions and has endorsed the PRAC's recommendations on the use of flupirtine-containing medicines," the statement said. "The CMDh position will now be sent to the European Commission, which will take a legally-binding decision to be valid throughout the EU."

Flupirtine is a nonopioid painkiller that has been used to treat pain such as that associated with muscle tension, cancer pain, menstrual pain and pain following orthopedic surgery or injuries. Flupirtine-containing medicines have been authorized since the 1980s and are currently available in EU member states Bulgaria, Estonia, Germany, Hungary, Italy, Latvia, Lithuania, Poland, Portugal, Romania, and Slovakia.

It is available as 100-mg immediate-release capsules, 400-mg extended-release tablets, 75-mg and 150-mg suppositories, and as a solution for injection (100 mg). The 100-mg immediate-release capsules are available in the 11 EU member states listed above. The other dosages and pharmaceutical forms are only available in Germany.

Re: Flupiritine

PostPosted: Tue Jul 30, 2013 11:29 am
by FluppyPuffy

Re: Flupiritine

PostPosted: Tue Jul 30, 2013 11:59 am
by TATT
Hi FP,

Yes your right and I will speak to the new doctor about this hopefully today I will let everyone know what he says. I have lost half my hair and it's still falling out now, not sure if this is to do with the pill but it has been mentioned by friends that it could be linked. When I was introduced they told me that not only hardly any side effects but there is no addiction, or is is something tolerance.

Means I can stop without withdrawals, but I should speak with the doctor, thanks. It is a shame as since taking it I now swim/walk twice a week which is a big step from being housebound the last two years. Bald or not life is getting better. Let's see what happens now.

Tatt x

Re: Flupiritine

PostPosted: Tue Jul 30, 2013 12:25 pm
by FluppyPuffy
The hair loss may be related to the med TATT, I know there are some that can cause the problem, and if you're on a combo of things, it could all be adding to it.

Being able to stop a med without withdrawals sounds wonderful, I know how bad I have felt at times when having to come off one gradually, plus I was once told to just stop taking everything I was on at the time which was the worst thing possible for me and set me back 6~12 months in all respects :nono: :nono: :nono: :nono:

The doc you have been seeing might have some suggestions for alternatives, as there may be several types/makes of similar meds to the flupirtine.

The name of it, flupirtine, keeps making me :mrgreen: :mrgreen: :mrgreen: :mrgreen: :mrgreen: :mrgreen: I think it must be because of it starting with flup, giving me strange images of a doggy~shaped pill for some reason :lol: :lol: :lol: :lol: :lol: :lol: :lol: :lol:

Re: Flupiritine

PostPosted: Tue Jul 30, 2013 6:18 pm
by Iceskatemum
I think if you have logged into the system once then it probably means that you can access it again but because I didn't log on I keep getting the log in page.

Re: Flupiritine

PostPosted: Tue Jul 30, 2013 6:30 pm
by FluppyPuffy
I didn't log in to it ISM, I found it when asking Dr Googley to have a look thru his Mega Encyclopaedia of Pills and Potions about it. As the articles have been copied to the topic, I'll remove the linkys so it won;t keep happening.

Re: Flupiritine

PostPosted: Wed Jul 31, 2013 12:26 am
by anonymouse
Interesting article, thanks to the Original Poster. I have had a look in the BNF and I can't find it at all in the UK. I have tried a few of the brand names from wiki too with no luck. I am guessing its not licensed for anything in the UK?

Re: Flupiritine

PostPosted: Wed Jul 31, 2013 10:22 am
by TATT
Hi Anonymouse,

No it's only available in the EU and you can get it through Prf Davies Clinic on a private prescription. I am still waiting to hear from the clinical manager but we spoke to the dispensing chemist and was reassured that I should keep taking it. I then found another. Article from America dated 2011.

That one said that a certain company had bought rights to the flupiritine, with use for fibromyalgia in a second clinical trial. So seems America is using it too. I will keep you posted when I know more.

Tatt

Re: Flupiritine

PostPosted: Wed Jul 31, 2013 12:48 pm
by Iceskatemum
Wonder if you can get it in Ireland?

Re: Flupiritine

PostPosted: Wed Jul 31, 2013 1:09 pm
by FluppyPuffy
I've only asked Dr Googly briefly, and his general comment is that it has been available in Europe since 1984. To help with your finding~outs tho, his friend Mr Wikipedia does say that it is available in Europe under these other names, Katadolon, Trancolong, Awegal, Efiret, Trancopal Dolo, and Metanor.